We did the Cherohala Skyway on one of the trips down south. It is a very scenic route with a waterfall towards the westend by Tellico Plains. As others have mentioned the Dragon is not as bad as the videos make it out to be if you ride like you have some sense. Weekday mornings are less crowded than the weekends on the Dragon. Enjoy your trip, you can't go wrong with any of the routes you have mentioned.
If you are making the trip all the way from Iowa you really need to ride the Tail of the Dragon. If you leave Gatlinburg and enter the Smokies and take a right on Little River Road it will take you through Townsend and over to the Foothills Parkway. The Parkway is a very scenic route and dead ends into 129. A left turn on 129 and in a few short miles you will enter the Dragon from the west side and be able to stop at Deals Gap at the east end and pickup a T-shirt. Jump on the Moonshiner 28 and take it to 74 and 74 to 441 which will take you through Cherokee and through the Smokies and return you to Gatlinburg. Have done this route a couple of times. It is an easy one day ride.
Don, I have stored my boat at Lake Cumberland for the past 25 years. It is a 5 hour trip from Piqua to Jamestown, Ky. When the kids were young we would make the trip every other weekend from Memorial Day to Labor Day. Now that the kids are grown and I bought the wing we make it to the lake about three times a summer. We ride the bike almost every evening during the summer. Kind of the opposite of what you are experiencing.
I quit when I was 12. Dad caught 2 friends and I smoking in the hay loft. He opened a can of whoop ass on the three of us that I won't ever forget. Didn't really feel like smoking after that.
don't use it to help mankind by building a touring motorcycle with fuel injection, cruise control, awesome audio, heated seats, heated grips, reverse, low center of gravity and a comfortable seat that you can ride to