If you are thinking mid to western Pa the Laurel Highlands area is really nice. Alot of history on rt 30 Lincoln Hwy. Frank Lloyd Wrights Falling Waters, flight 93 Memorial is beautiful. also Quecreek mine site of the 2002 rescue is pretty interesting. We stayed at Ligoneer Inn I think, nice place with restaurant onsite. Gettysburg is a great area for history buffs, the HD plant in York is said to have nice tours. Lancaster County has lots to see and do and great roads. If you are coming my way let me know.
Craig