Years ago I had a Ford with two fuel tanks, i would always switch tanks before it would run out. One day i missed and it sucked the tank dry along with all the crap at the bottom of the tank, there I was on the side of the road changing a fuel filter.
For the same reason I always run on reserve and trust the count down/light will remind me to fuel up. I would be concerned about the crap accumulating at the bottom of the tank if you don't get into reserve regularly.