Get on I-81, stay on it to Marion Va. Take Rt16 from Marion, VA to Beckley, WV. At Beckley pick which interstate gets you to where you need to be. This route will clearly take you longer, but Rt16 is a simply wonderful ride. In fact the first 33 miles is refered to as 'Back of the Dragon'. If you want a t-shirt for the ride... stop in Thompson Country Store shortly before you get to Tazewell, VA