I have larger hands as well.. I have a Taurus PT740 (.40) as CC, little small, but with the grip extension it fits fine, and I don't notice it when I carry it. I also shoot and sometimes carry a Springfield XD 40 (.40), and Taurus PT92AF (9mm).
Springfield is a great gun. Have over 1K rounds through it, no jams, very well balanced, fits my hand great, and accurate.
Taurus 92 is a bigger pistol, also over 1K rounds down range, 5 inch barrel, but its basically the same sidearm I carried for 20 years in the service. Knockoff Beretta. Also fits great, eats any brand of ammo I feed it, very accurate. (can hit a 1 foot plate at 75 yards 80-90% of the time).
Dad has hands like mine and swears by his Beretta PX Storm. The you can change out the spine of the grip to make the grip bigger. We also put a pachmyr (sp) rubber slide on grip over it, and he love it. Uses it as his CC.
Best opinion I can give.. go to the counter and see what fits your hand right. Do research on reliability.. and see if the gun counter has a "try before you buy" rule. Sometimes, they have a used model they will let you shoot before you buy new. Never hurts to ask.